ROLE OF APOLIPOPROTEINS (APO A1/ APO B) IN NON- ALCOHOLIC FATTY LIVER DISEASE (NALFD)

Abstract

Introduction-   A more general name for patients with simple steatohepatitis and steatosis, which can progress to liver cirrhosis or even hepatocellular cancer, is non-alcoholic fatty liver disease (NAFLD). Roughly 90% of NAFLD patients with simple steatosis and steatohepatitis will not have a higher death rate, however 10% to 30% of patients with NASH (non-alcoholic steatohepatitis) may experience inflammation and hepatocellular damage. As a result, cirrhosis, increasing fibrosis, and end-stage liver disease occur in 25–40% of NASH patients.

Material and Methods-  It was a Hospital Based Cross Sectional Observational Study, Duration 2 years and this study was include a total 140 subjects, which will divided in two groups Group I and Group II.

Result- In our study we conclude that the level of Apo A1 is higher (2.42±0.54) in grade I and (7.27±1.25) in grade II when compared with controls (1.49±0.27) having p value <0.05 and t value 15.06. In our study we conclude that the level of Apo B is lower in cases (0.72±0.12) and (0.33±0.13) in group 1 and group 2 when compared with controls

(1.00±0.17) having p value <0.05.

Conclusion- Our study's results indicate that alterations in the levels of apoA1 and apo B and   contribute to the disease's worsening.  Our findings imply that the severity of NAFLD may be correlated with an increase in Apo A1 level and a decrease in Apo B level. In our study we find a positive correlation between Grade 1 and Grade 2 NAFLD patients.