THE RELATIONSHIP BETWEEN GENETIC VARIATIONS IN MTHFR C677T AND MTRR A66G GENES IN METABOLIC SYNDROME PATIENTS IN THE DEMOGRAPHIC OF NORTH INDIA

Abstract

Abstract

Introduction: Metabolic Syndrome (MetS) presents a complex interplay of metabolic factors contributing to cardiovascular diseases and type 2 diabetes, with genetic variations being implicated in its etiology.

Methods: This study explores the relationship between genetic variations in MTHFR C677T and MTRR A66G genes and MetS in a North Indian demographic. A case-control study involving 400 individuals was conducted, with clinical, demographic, and molecular parameters assessed.

Results: Genotyping analysis revealed no significant correlation between MTHFR C677T variation and MetS, as evidenced by adherence to Hardy-Weinberg equilibrium and nonsignificant chi-square values. Similarly, MTRR A66G variation showed no substantial association with MetS.

Conclusion: These findings suggest that these genetic variations may not confer susceptibility to MetS in this population. Further research is warranted to elucidate the role of these genes in other metabolic disorders and populations.