NON-ALCOHOLIC FATTY LIVER DISEASE: A SILENT CONTRIBUTOR TO CARDIOVASCULAR DISEASE RISK

Abstract

Introduction: NAFLD, marked by liver fat accumulation unrelated to alcohol consumption, is now acknowledged as a significant contributor to cardiovascular risk. Understanding this association is crucial for effective risk management.
Objectives: This review aims to elucidate mechanisms connecting NAFLD and CVD, assess prevalence of cardiovascular risk factors in NAFLD, evaluate intervention effects, and investigate NAFLD's predictive value for cardiovascular outcomes.
Results & Observations: NAFLD is linked with insulin resistance, inflammation, dyslipidemia, and hepatic dysfunction, elevating CVD risk. Individuals with NAFLD commonly exhibit obesity, type 2 diabetes, hypertension, and dyslipidemia. Lifestyle changes and certain medications improve cardiovascular risk factors in NAFLD patients. NAFLD severity correlates with severity of risk markers and predicts adverse cardiovascular outcomes.
Conclusion: NAFLD significantly increases CVD risk. Comprehensive management strategies, including lifestyle modifications and pharmacological interventions, are crucial for mitigating this risk. Early detection and intervention are vital for preventing CVD development and progression in NAFLD patients.