SEROLOGICAL DETECTION OF INTERLEUKINS IL-22 AND IL-37 IN CHILDREN INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS IN DIYALA GOVERNORATE, IRAQ

Abstract

Abstract:

Respiratory Syncytial Virus is the primary reason for acute viral bronchiolitis and pneumonia among newborns additionally to young children. This study proposes to find antiRSV IL-22 and IL-37 antibodies in infants and kids from six months to five years old. ELISA was used to measure serum levels in 94 people (50 with respiratory symptoms and 44 healthy controls). The clinical grouping covers people hospitalized with acute respiratory symptoms and/or chest pain at Albatool Teaching Hospital for Children in Baqubah, Diyala governorate, based on their infection severity. ELISA results showed that patients had anti-RSV IL-22 serum levels of (173.25 ±72.8) while controls had levels of (79.59 ±47.36). IL-37 patients had blood levels of (30.49 ±13.9), while control subjects had serum levels of (12.22 ±4.57). The study found that all groups had a high percentage of IL-22 and IL-37 antibodies against the RSV virus. Early diagnosis of viral infection is advised since elevated levels are likely to be associated with infection start. Primary infection with the RSV virus, regardless of severity. These findings may help us better understand the transmission of RSV among infants and kids, in addition to the prevalence of RSV-infected respiratory tracts, potentially leading to fewer unnecessary antibiotic prescriptions in the community.