EVALUATION OF MYOSIN BINDING PROTEIN- C3 (MyBP-C3) IN SERUM OF MEN HYPERTENSIVE PATIENTS
Main Article Content
Abstract
Introduction: Hypertension is often referred as a silent killer disease, because it is often patients for years without feeling any disturbance or symptoms. (Myosin binding protein-C slow) comprises a family of accessory proteins in skeletal muscles that bind both myosin and actin filaments. MyBP-C is a thick filament regulatory protein that is only present in the vertebrate striated muscle sarcomeres' C-zone of the A-band. The roles of the cardiac, slow skeletal, and fast skeletal MyBP-C (fMyBP-C) paralogs are distinct. Although the three paralogs' protein structures are similar, their expression and functions most likely differ significantly, which may be necessary to support the different physiologies of fast and slow muscle fibres..
Methods: The case-control study included (90) subjects divided into (60) male patients. Samples were collected for patients with high blood pressure. Height and weight were measured, and other information was also collected. The ELISA test was performed. control group study of 30 men was also conducted. All groups that appeared healthy were matched in age.
Results: a significant positive correlation between MyPBC-3 and cholesterol, TG and LDL-C while indicate a negative correlation with HDL. These results were documentation in currant study and no previous studies deals with the relation between MyPBC-3and lipid profile, also High biomarker level associated with ages especially at new diagnosis without treatment and with short duration of disease. The genetic, Smoking and Obesity play acrucial role in present study by high level of MyPBC3 in familial hypertensive patients.
Highlights
The exact Structure of arrangement Knowledge of the relationship between thick and thin filaments and cMyBP-C facilitates comprehension of the consequences of cMyBP-C phosphorylation, which is essential for regular cardiac function and seems to guard against ischemia harm., also (cMyBP-C) is a sarcomere thick filament-associated protein that may be used as a therapeutic target to treat heart failure's contractile dysfunction.
Present study concluded MyBC3 considered as a progress marker for prediction of hypertension. Significant positive correlation between MyPBC-3 and lipid profile also other factors such as genetic and age.
significant positive correlation between MyPBC-3 and cho, TG and LDL-C while indicate a negative correlation with HDL. These results were documentation in current study. The genetics, Smoking and Obesity play a crucial role in present study by high level of MyPBC3 in familial hypertensive patients.
Conclusions: present study concluded MyBC3 considered as a progrestc marker for prediction of hypertension.