EFFECT OF STRESS MEASURED BY SALIVARY STRESS BIOMARKERS ON THE SPERM PARAMETERS OF IRAQI INFERTILE MEN

Abstract

Abstract:

Background: The inability to conceive after a suitable period of sexual activity without taking any contraceptive measures is known as infertility. Forty to fifty percent of cases of infertility are male-related. One important measure of the health of the male reproductive system is semen quality. Stress is bad for the body and can cause a number of health problems. Both men and women experiencing infertility without apparent explanation have had stress examined as a potential contributing factor. In roughly 30% of cases, the etiology of the illness is never identified; these cases are categorized as idiopathic.

Patients, Material and Method:100 males with the challenge of infertility were included in a cross-sectional study, and their results were split into 25 normozoospermia, 26 oligozoospermia, 21 asthenozoospermia, and 28 oligoasthenoteratozoospermia of infertile men. The ELISA technique was utilized to assess salivary cortisol and alpha-amylase, and the WHO 2021 criteria were followed to examine the semen after it had been liquefied.

Results: The mean salivary stress biomarkers (SAA and cortisol) compared a cross all research with groups reveal positive significant differences with cortisol ( p= 0.022) and SAA  (p = 0.016). In the current investigation there was strong positive significant association ( r = 0.398 & p = 0.049) btween SAA andconcentration of sperm  normozoospermia and high negative  significant correlation (r = - 0.275 & p =0.006) btween SAA and motility progressive (A+B)  in  study groups. Saliva cortisol was significantly correlated negatively with both sperm concentration (r = 0.240 & p = 0.016) and sperm count (r = 0.255 & p = 0.010). In OAT, there was a substantial positive connection between saliva cortisol and round cells (r = 0.377& p = 0.048) and sperm count (r = 0.475& p = 0.011).

Conclusion: Saliva cortisol and SAA levels that are higher in infertile men exhibit both positive and negative correlations with sperm concentration, sperm count, and motility. In oligoastheratozoospermia, there is a positive correlation between sperm count and round cells, and a positive correlation between SAA and sperm concentration in normozoospermia.