ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF MIMOSA PUDICA LINN

Abstract

Introduction: Diabetes is a metabolic disorder of high blood sugar levels which leads to various chronic health-related complications. The digestive enzymes α-amylase and α-glucosidase play a major role in the hydrolysis of starch to glucose; hence, inhibiting these enzymes is considered an important strategy for the treatment of diabetes. Medicinal plants such as Bergenia ciliata, Mimosa pudica, and Phyllanthus emblica are commonly used in traditional remedies due to their numerous health benefits.

Aim and Objective: To evaluate the alpha glucosidase inhibition activity of Mimosa pudica and to find the alpha glucosidase inhibition activity of Mimosa pudica.

Materials and Methodology: Cell viability assay and molecular docking were analyzed on Mimosa pudica Linn. Biologically safe or noncytotoxic concentration of plant extracts and cytotoxicity of ethanol were identified using MTT and NRU assays. Molecular docking was also performed.

Results: The results were expressed as percentage inhibition, which was calculated using the formula,

Inhibitory activity (%) = (1 − As/Ac) ×100. The ethanolic plant extract was compared with acarbose. Various concentrations such as 2 mg, 4 mg, 6 mg, 8 mg and 10 mg were considered.

When comparing the standard with the ethanolic plant extract, significant similarities were observed

Conclusion: From this study it can be concluded that Mimosa pudica plays a role in alpha glucosidase inhibition and can be useful in controlling diabetes.