FREE RADICAL SCAVENGING OF ZINC OXIDE NANOPARTICLES SYNTHESIZED USING RUBIA CORDIFOLIA

Abstract

INTRODUCTION: Zinc oxide nanoparticles (ZnO NPs) have gained significant attention due to their potential applications in various fields, including medicine and cosmetics. However, their inherent reactivity and ability to generate free radicals raise concerns about their potential toxicity.

 To mitigate these concerns, researchers have explored natural sources for the synthesis of ZnO NPs, such as Rubia cordifolia, a medicinal plant known for its antioxidant properties.

This study aims to investigate the free radical scavenging activity of ZnO NPs synthesized using Rubia cordifolia extract. Understanding the potential antioxidant properties of these nanoparticles is crucial for assessing their safety and potential use in biomedical applications.

AIM: To study about the free radical scavenging activity of zinc oxide nanoparticles synthesized using rubia cordifolia.

MATERIALS AND METHODS: Zinc oxide nanoparticles were synthesized using Rubia cordifolia extract as the reducing agent. Zinc acetate dihydrate and Rubia cordifolia extract were mixed and heated at 90 degree celsius for 3 hours. The nanoparticles were characterized by UV-Vis spectroscopy and XRD. Free radical scavenging activity was evaluated using DPPH assay. The concentration required to scavenge 50% of DPPH radicals was determined.

DISCUSSION: The resulting ZnO NPs exhibit unique physicochemical properties, including a high surface area, small size, and enhanced reactivity, which make them suitable candidates for free radical scavenging.

The free radical scavenging activity of ZnO NPs synthesized using Rubia cordifolia can be attributed to their inherent antioxidant properties. These nanoparticles possess a large number of surface-active sites, allowing them to efficiently scavenge free radicals by donating electrons or hydrogen atoms.

RESULTS: The zinc oxide nanoparticles that were synthesized showed free radical scavenging activity.

CONCLUSION: In conclusion, the synthesis of zinc oxide nanoparticles using Rubia cordifolia has demonstrated potential antioxidant properties through its free radical scavenging activity. The study revealed that these nanoparticles possess the ability to neutralize harmful free radicals, thereby reducing oxidative stress and potentially offering protection against various diseases associated with oxidative damage.