ONE POT SYNTHESIS OF Ag@Ag₃Po₄-g-C₃N₄ AND ITS CYTOTOXICITY STUDIES ON ORAL CANCER CELL LINES

Abstract

INTRODUCTION: For their distinct physicochemical characteristics and possible anti-cancer benefits, silver nanoparticles (AgNPs) have been the subject of substantial research. Ag3PO4-c3N4, a composite material made of graphitic carbon nitride (c3N4) and silver phosphate (Ag3PO4), has the benefit of combining the cytotoxic effects of silver with the photocatalytic activity of c3N4. Targeted therapy is made possible and the anti-cancer properties of silver nanoparticles are enhanced by this combination.

AIM: The aim of the study is to investigate the cytotoxicity and anti-cancer properties of the one-pot synthesised Ag@Ag3PO4-c3N4 nanoparticles on oral cancer cell lines

MATERIALS AND METHODS: Heat it up to 180 °C and maintain it for 16 hrs to promote the reaction and formation of silver phosphate.Wash ppt with ethanol to remove impurities Dry at 150 °C for 12hrs.Add Ag nanoparticles to the materials using ultra sonification for 3 h and then filtration, dry for 3hrs at 90 °C.Ag@Ag₃Po₄-gC₃N₄ is prepared.

RESULTS: X-ray diffraction is used to analyse the phase structure of our material from the refractory plane we confirm that our materials are highly crystalline and the presence of Ag@Ag₃Po₄-g-C₃N₄ present in the material.SEM explains the surface morphology of Ag@Ag₃Po₄-g-C₃N₄ most of the particles are cluster like structure and also have small particles that belong to silver.SEM image have the large number of void and structure it act as the active site for the material and also further we confirm that the element present in our material is C,O,N,P,Ag conform the formation of material and no other impurities are present.

CONCLUSION: The one-pot synthesis of Ag@Ag₃Po₄-g-C₃N₄ nanoparticles presents a promising avenue for oral cancer treatment. The demonstrated cytotoxicity on oral cancer cell lines suggests their potential as a therapeutic agent.