OSTEOGENIC EVALUATION OF METAL NANOPARTICLES COATED TITANIUM IMPLANTS FOR BONE REGENERATION
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Abstract
Introduction : Infection and inflammation play a role in healing and soft tissue integration, which can lead to some dental implant therapy failures. When dental implants are surgically placed into the jawbones, a process known as osseointegration, which is the biological fixation of the implants, takes place. The long-term success of implant-supported prostheses is thought to depend on such a fixation. Nanotechnology advancements have given us solutions for bone tissue engineering. This study's objective is to assess the osseointegration capacity of titanium implants covered with CuO and ZnO for bone regeneration.
Materials and methods : CuO & ZnO NPs, Ti implant, osteogenic medium, RT-PCR for Run x2, ALP & Col-I expression
Results : The PCR results show that the expression of Run x2 and ALP were high in coated implant whereas they were low and equal in non coated implant and normal cells.
Conclusion : Run x2 has increased in coated implants and it also enhanced the proliferation of alkaline phosphatase (ALP) activity of osteoblast. Hence, metal coated implants are better over non coated implants to promote osseointegration.