PERIPHERAL NEUROPATHY IN DIABETIC VS. NON-DIABETIC PATIENTS: A COMPARATIVE STUDY

Abstract

Peripheral neuropathy is a common neurological disorder affecting both diabetic and non-diabetic populations worldwide. This study aimed to compare the prevalence, risk factors, pathophysiology, clinical manifestations, diagnosis, management strategies, and future directions of peripheral neuropathy in diabetic and non-diabetic patients. Our analysis revealed distinct differences in prevalence rates, risk factor profiles, and underlying pathophysiological mechanisms between diabetic and non-diabetic neuropathies. While both groups exhibited similar clinical manifestations, including sensory, motor, and autonomic symptoms, variations in symptom presentation and disease progression were noted. Diagnostic modalities such as clinical assessment, neurophysiological testing, laboratory investigations, imaging studies, and skin biopsy were employed to evaluate peripheral neuropathy in both populations. Management strategies encompassed pharmacological interventions, lifestyle modifications, physical therapy, and alternative therapies, with a focus on symptom relief and prevention of complications. Future directions include advancements in understanding pathophysiology, precision medicine approaches, development of disease-modifying therapies, integration of digital health technologies, and multidisciplinary collaborative care models. Overall, this study underscores the importance of tailored approaches to peripheral neuropathy management based on individual patient characteristics and highlights the need for continued research and innovation to improve outcomes for affected individuals.