SEPSIS AND SEPTIC SHOCK: AN UPDATE ON CLINICAL MANAGEMENT AND OUTCOMES
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Abstract
Introduction: Sepsis represents a significant healthcare burden, with millions of cases worldwide and high mortality rates. Despite advancements in management, challenges persist, necessitating ongoing research and improvement efforts. This paper aims to provide an updated overview of sepsis management, highlighting recent progress and areas needing further attention.
Objective: The objective of this research paper is to review the pathophysiology, diagnosis, clinical management strategies, and emerging therapies for sepsis and septic shock. By summarizing key findings and current practices, we aim to enhance understanding and inform clinical decision-making to improve outcomes for septic patients.
Results: Key findings from this review include insights into immune dysregulation mechanisms, diagnostic criteria, resuscitative measures, and emerging therapies such as immunomodulatory interventions and precision medicine approaches. Challenges in diagnosis, management, and survivorship are also highlighted, underscoring the need for continued research and innovation.
Conclusion: In conclusion, sepsis management requires a multifaceted approach encompassing early recognition, appropriate resuscitation, targeted antimicrobial therapy, and supportive care. Emerging therapies hold promise but require further validation and implementation. Continued collaboration, research, and personalized care are essential for improving outcomes and reducing the global burden of sepsis.