IN-VITRO ANTI LIPASE ACTIVITY OF POLYHERBAL SIDDHA FORMULATION ILAVANGATHI CHOORANAM

Abstract

Obesity is a metabolic disorder that has emerged as an alarming condition worldwide. This results from the interaction of biological, psychological, and environmental factors that impact an individual's quality of life. Obesity leads to cause many chronic diseases like diabetes, hypertension and cardiovascular diseases. Pancreatic lipase (PL) is plays the major role in the absorption of dietary lipids. Inhibition of pancreatic lipase is one of the study to determine the anti obesity agents. In Siddha system of medicine, Ilavangathi chooranam (IVC) is widely used for dyslipidemia, atherosclerosis of heart and obesity etc by Siddha practitioners.  Hence, we aimed to see whether Ilavangathi chooranam could be used as a potential source of new lipase inhibitors.  An in vitro study, which was performed to check its anti-lipase activity, showed a potent lipase inhibition with IC50 of 273.21±4.18μg/ml compared to orlistat with IC50 of 0.3μg/ml.  Finally this study suggests that the Ilavangathi Chooranam possess the best therapeutic action in the treatment of obesity.