EXPLORING THE LINK BETWEEN METABOLIC SYNDROME AND HEMOLYTIC ANEMIA: A CASE-CONTROL STUDY

Abstract

Metabolic syndrome (MetS) has been associated with various adverse health outcomes, including cardiovascular diseases and type 2 diabetes mellitus. However, its potential link with hemolytic anemia remains underexplored. This case-control study aimed to investigate the association between MetS and hemolytic anemia and explore potential underlying mechanisms. Participants were recruited from diverse healthcare settings, including hospitals and community health centers. Demographic information, medical history, anthropometric measurements, and biochemical parameters were collected. The prevalence of MetS and its components was compared between individuals with hemolytic anemia and age- and sex-matched controls. Logistic regression models were used to assess the association between MetS and hemolytic anemia, adjusting for potential confounders. Results revealed a higher prevalence of MetS among individuals with hemolytic anemia compared to controls. Dyslipidemia and central obesity emerged as significant predictors of hemolytic anemia risk. Mechanistically, oxidative stress, inflammation, and endothelial dysfunction were implicated in the association between MetS and hemolytic anemia. These findings underscore the importance of considering metabolic factors in the assessment and management of hemolytic anemia. Early detection and targeted interventions for MetS may help mitigate the risk of developing hemolytic anemia and improve patient outcomes. Further research is warranted to elucidate underlying pathways and inform personalized approaches to prevention and treatment.