GENETIC INVESTIGATION OF THE RISK OF INTERLEUKIN-13 LOCUS RS200196698 IN DIYALA WOMEN WITH VAGINITIS

Abstract

Abstract

    Bacterial vaginosis (BV) is considered as the most prevalent vaginal disease worldwide. The current study aimed to detect the risk relative of genotypes of interleukin-13 locus rs200196698 in Iraqi women who diagnosed with BV. Genomic DNA was extracted from 70 blood samples, which were split between pregnant women who tested positive for BV and control (non-pregnant women) in the ratio of 57 to 13 respectively. The study has demonstrated that the women with BV exhibited a higher frequency of the homozygous genotype GG and G alleles which mirror a higher chance of developing BV than control women, with OR values of 3.97 and 3.59, respectively. On the other hand, homozygous genotype AA and A alleles in the IL13-3596 SNP rs200196698 were protective agents against BV with OR (0.00) and (0.28) respectively compared to controls. The findings of this study have shown that host genetic variations at the IL13 SNP have roles in increasing risk relative to genotypes and increasing the ability to BV among pregnant Iraqi women. In conclusion, Individuals with homozygous GG genotypes were at increased risk of developing BV. It's probable that this predisposes women to developing BV.