IRRITABLE BOWEL SYNDROME AS AN EARLY DETECTOR OF INSULIN RESISTANCE AND PREDIABETES IN OVERWEIGHT ADULTS

Abstract

Abstract

Background: Irritable bowel syndrome (IBS) is a common condition that significantly decreases the patients' quality of life. T2DM may exacerbate symptoms of IBS.

Aim: To recognize the possible role of IBS as an early detector of insulin resistance and prediabetes among overweight adult persons.

Methodology:  A comparative trial that included 200 participants who were divided into 2 groups, each group included 100 individuals. Group A (IBS group) and Group B (Non-IBS group). BMI, FBG, HbA1c, liver enzymes (ALT, AST), and lipid profiles were evaluated. Clinical evaluation of IBS symptoms and Abdominal Ultrasound were performed. The Statistical analysis was conducted by SPSS. Descriptive data (e.g., frequencies and percentages) were calculated, and the x 2 test and t test were applied accordingly. A p-value less than 0.05 was considered significant.

Results: The mean baseline HbA1c level among Group A was 5.945 (t= -29.070, p<0.001), and 5.314 (t= -76.992, p<0.001), in Group B. FBG levels were 99 mg/dL. ALT and AST levels in Group A were 42.54 (t= -1.064, p=0.290) and 4.78 (t= -1.850, p=0.067), respectively, with no significant difference. In Group B, ALT and AST levels decreased significantly to 36.79 (t=-9.137, p< 0.001) and 5.46 (t= -5.608, p< 0.001), respectively. In Group A, triglycerides and ultrasound mean was 191.58 (SD=66.68) (t= 6.236, p<0.001) with significant increase, with a confidence interval (28.35, 54.81), while In Group B, they were154.41 (SD=28.85), with no statistically significant difference (t=1.529, p=0.130). The mean BMI at baseline for Group A was 29.33, significantly elevated (t=8.883, p<0.001) while in Group B it was 24.316, significantly lower than the test value (t= -2.793, p=0.006).

Conclusion: IBS can be not only as a digestive disorder but also as a potential warning sign for broader metabolic issues like insulin resistance.