EVALUATING THE EFFECTIVENESS OF ORAL NIFEDIPINE VERSUS TRANSDERMAL NITROGLYCERINE FOR TOCOLYSIS IN PRETERM LABOR: A PROSPECTIVE ANALYSIS

Abstract

Introduction: Through this paper, we hope to improve the quality of evidence-based care for preterm labour and, in the process, the health of women and their babies. Neonatal outcomes, rates of preterm delivery within 48 hours, and the amount of time needed for successful tocolysis will all be included in the review. The results of this study have the potential to enhance the quality of preterm labour treatment and therefore improve the health of mothers and babies.

Aim and Objective: The purpose of this study is to evaluate and compare the tocolytic efficacy of transdermal nitroglycerine patches and oral Nifedipine tablets in the treatment of premature labour. Examining the tocolytic effect especially related to oral Nifedipine and comparing the effectiveness of these two therapies in preventing premature contractions are the main goals.

Methods and Material: The efficacy of tocolytics in treating premature labour was thoroughly investigated using a prospective trial that contrasted oral nifedipine with transdermal nitroglycerine patches. Through careful patient selection, randomization, and regular monitoring, the study prioritises patient safety and improves external validity, guaranteeing accurate comparisons between the two therapies.

Result: In this study, 120 pregnant women who were experiencing preterm labour were tested for tocolytic efficacy between nitroglycerine patches and oral nifedipine. The distributions of maternal age, gestational age, and parity were comparable. Nitroglycerine caused more headaches and hypotension, which led to a higher rate of discontinuations, but cervical dilation did not differ significantly. Because oral nifedipine is readily available and safe, its overall efficacy was comparable.

Conclusion: The nitroglycerine patch and oral nifedipine groups did not significantly differ in terms of obstetrical history or baseline indicators, according to the study. Despite the fact that the p-value was greater than 0.05, suggesting similar tocolytic effects, oral nifedipine was preferred due to its longer pregnancy extension and better safety record.