PREDICTIVE MARKERS FOR ADVERSE PREGNANCY OUTCOMES: INSIGHTS FROM A PROSPECTIVE COHORT STUDY ON MATERNAL FACTORS, BIOMARKERS, AND UTERINE ARTERY DOPPLER RESULTS

Abstract

Abstract

Background: Complications in pregnancy, such as preterm delivery, pregnancy-induced hypertension (PIH), and intrauterine growth restriction (IUGR), demand effective predictive strategies for improved outcomes. This study explores associations between maternal factors, first-trimester biomarkers, and second-trimester uterine artery Doppler results to enhance early risk detection and treatment.

Methods: A prospective cohort study of 500 antenatal women investigated correlations between demographic variables, maternal dual test markers (serum beta-HCG, serum PAPP-A), and uterine artery Doppler studies. Statistical analyses assessed associations with preterm birth, PIH, and IUGR.

Results: Serum beta-HCG levels below the 5th percentile correlated significantly with preterm birth (RR 2.3131, p = 0.0288). Low serum PAPP-A levels (<5th percentile) associated with PIH (RR 2.1447, p = 0.0204) and IUGR (RR 2.0953, p = 0.0002). Uterine artery Doppler indices (>0.58 RI) demonstrated associations with PIH (RR 2.2448) and IUGR (RR 1.6293). Diastolic notching correlated with preterm birth, PIH, and IUGR.

Conclusions: This study identifies serum beta-HCG, PAPP-A, and uterine artery Doppler indices as valuable predictors for adverse pregnancy outcomes, emphasizing their potential in early risk detection.