ESTIMATION OF NESFATIN-1 AND FETUIN-A WITH SAME RELATED PARAMETERS IN OBESE AND NON OBESE MENOPAUSE WOMAN

Abstract

Abstract

Background: Menopause is an aging in woman, it begins in most of them  at 45 years old, the main reason of menopause is the decline of the Estrogen hormone result from decline of ovaries function, it's include many of symptoms such as nocturnal sweats, hot flashes, depression, elevated of anxiety, insomnia, sleep disturbance, genitalia include inflammation, dryness, urinary tract infections, painful urination, gaining weight, usually in the abdomen, hips and joint pain. Menopause leads to many disease from them insulin resistance and obesity. The adipose tissue it's secretes active proteins such as nesfatin-1 which is adipocytokines regulates food intake. Fetuin-A is adipokines and hepatokiens that generated mainly by liver it serves to act as carrier of free fatty acid in circulation.

Objectives: The aim of this study is to estimate nesfatin-1, fetuin-A hormones and other related parameters in obese and non-obese menopause woman.

Material and Methods: This study involved 90 woman. For comparison, included (45) non-obese menopause woman weight with BMI (22.08±3.39) Kg/ m2 as a control group (group1), another (45) obese menopause woman with BMI (35.38±2.52) Kg/ m2 group2.

Results: There is significant decrease at (P≤ 0.001) in the level of nesfatin-1, E2 and significant increase at (P≤ 0.001) in the level of fetuin-A, FSH, LH and TNF-α in group2 compered to control group, also there is a significant elevation at (P≤ 0.001) in homeostatic model assessment- insulin resistance

(HOMA-IR) compared to control group.

Conclusion: nesfatin-1, E2 hormone decrease significantly, but fetuin-A, FSH, LH and TNF-α significantly increase and elevated with insulin resistance in obese menopause woman compered to control group.