STUDY OF THE SYNERGISTIC EFFECT OF METHIMAZOLE AND AQUEOUS EXTRACT OF LICORICE ON THE LEVEL OF THYROID HORMONES IN RATS

Abstract

Abstract
This study was conducted at the University of Tikrit, College of Education for Pure Sciences, Department of Biology, in 2024, on the licorice plant, to study the synergistic effect of the drug methimazole and the aqueous extract of the licorice plant, to reveal the effective biological active compounds contained in this plant and the effect of these compounds on the level of T3 thyroid hormones. And T4 and TSH, are the active compounds detected in the aqueous extract of the licorice plant, which are phenols, flavonoids, alkaloids, glycosides, and tannins. In this study, 10 rats were divided into two groups. The first group was the control group, and the second group was the group treated with the drug methimazole and the aqueous extract of the licorice plant. The results showed that the treatmentwith the drug  Methimazole and the aqueous extract of the licorice plant affected the level of thyroid hormones, as it was observed that there was a significant decrease (P ≤ 0.05) in the level of the thyroid hormones T3 and T4 and the thyroid stimulating hormone (TSH) in the blood serum of the group treated with methimazole and the aqueous extract of the licorice plant compared to the control.