Psoriasis as a Risk Factor for Venous Thromboembolism: Surgical Implications

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Dr Sharayu Deshmukh, Dr S J Bhosale , Dr Anuroop Bhakkad


Psoriasis, an immunoinflammatory disease, is recognized for its association with cardiovascular risk factors, atherothrombotic events, and hypercoagulability. Venous thromboembolism (VTE), a potentially fatal condition, shares common risk factors with psoriasis, yet the specific risk of VTE in psoriasis patients remains uncertain. This study aimed to explore the potential link between psoriasis and VTE, with particular attention to its implications for surgical interventions. Utilizing nationwide prospectively recorded data from hospitalizations, pharmacy dispensing, socio-economic records, and causes of death, individual-level analysis was conducted. Within an unselected nationwide cohort, multivariate Poisson regression models were employed, controlling for age, gender, comorbidity, concomitant medication, socio-economic status, and calendar year, to evaluate the VTE risk associated with psoriasis. The study identified 35,138 patients with mild psoriasis and 3,526 with severe psoriasis, comparing them with 4,126,075 controls. Patients with psoriasis exhibited higher incidence rates of VTE per 1000 person-years compared to controls (1.29, 1.92, and 3.20 for controls, mild psoriasis, and severe psoriasis, respectively). The rate ratio (RR) of VTE was elevated among all psoriasis patients, with RR values of 1.35 (95% confidence interval [CI] 1.21–1.49) for mild psoriasis and 2.06 (CI 1.63–2.61) for severe psoriasis. Even after excluding patients with malignancies and censoring those undergoing surgery, the results remained consistent. This nationwide cohort study underscores that patients with psoriasis face an increased risk of VTE, particularly pronounced in young individuals with severe psoriasis. Clinicians should be vigilant, recognizing the elevated risk of both venous and arterial thromboembolic events in psoriasis patients, with profound implications for surgical decision-making and post-operative management.

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Dr Anuroop Bhakkad , D. S. D. D. S. J. B. ,. (2024). Psoriasis as a Risk Factor for Venous Thromboembolism: Surgical Implications. Obstetrics and Gynaecology Forum, 34(3s), 1057–1062. Retrieved from

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