Analytical Approach to Vascular Screening for Pathological Angiogenesis: Surgical Implications

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Dr Dhaktode Chirag , Dr A.Y. Kshirsagar , Dr. Mahesh Kinikar

Abstract

Abstract
Investigating the intricacies of vascular dynamics and angiogenic processes is pivotal for refining surgical approaches in the context of pathological angiogenesis. This study delves into the correlation between microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HCC) and adjacent liver tissues. Quantitative reverse-transcription polymerase chain reaction (RT-PCR) and immunostaining were employed to evaluate MVD and VEGF expression in 71 patients who underwent curative hepatic resection for HCC. Utilizing a computer image analyzer–cell analysis system (CAS), VEGF immunoreactivity was quantified. Furthermore, angiographic data were juxtaposed with MVD in 50 tumors. Notably, tumoral MVD exhibited significant correlations with tumor capsule formation, with smaller HCCs demonstrating lower MVD compared to moderate-sized ones. Intriguingly, tumor vascularity on angiography did not align with MVD. While VEGF expression in HCC did not correlate with tumoral MVD or histopathological features, cirrhotic livers exhibited significantly elevated MVD and VEGF expressions compared to noncirrhotic livers. Crucially, tumoral MVD emerged as a significant predictor for intrahepatic recurrence and disease-free survival rates, independently influencing disease-free survival. This study underscores the nuanced interplay between MVD, VEGF, and prognosis in HCC, emphasizing its relevance in informing surgical strategies targeting pathological angiogenesis.
 

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Dr. Mahesh Kinikar , D. D. C. , D. A. K. ,. (2024). Analytical Approach to Vascular Screening for Pathological Angiogenesis: Surgical Implications. Obstetrics and Gynaecology Forum, 34(3s), 1032–1038. Retrieved from http://obstetricsandgynaecologyforum.com/index.php/ogf/article/view/415
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