HORMONAL PROFILE AND THEIR ASSOCIATION WITH PCOS AND FIBROID INCIDENCE IN YOUNG PAKISTANI WOMEN

Abstract

This study was carried out to evaluate levels of fertility hormonal profile in women with intramural fibroid and PCOS. A total of seventy-five 150 patients aged 18–50 years were recruited for the study and were divided into two groups: subjects with intramural fibroid group and PCOS group. The serum follicle-stimulating hormone, luteinizing hormone, Estradiol and prolactin were assayed using the ELISA method. The data was analyzed using SPSS Version 21.0. The probability p = 0.005 was statistically significant. The result obtained showed a significant increase (p = 0.005) in follicle stimulating hormone (9.37±0.37 mIU/mL) in patients with intramural fibroid group when compared with follicle stimulating hormone (6.72±0.48 mIU/mL) in PCOS. There was a significant increase (p = 0.005) in luteinizing hormone (6.19±0.27 iu/ml) in the fibroid uterus group when compared with luteinizing hormone (5.36±0.21 iu/ml) in the PCOS group. There was a significant increase (p = 0.005) in estradiol (207.81±218.694 pg/ml) in the uterine fibroid group when compared with oestradiol (88.14±16.79 pg/ml) in the PCOS group. There was a significant increase (p = 0.005) in prolactin (73.34±9.68µg/l) in the uterine fibroid group when compared with prolactin (14.67±10.96µg/l) in PCOS. It was however confirmed that patients with intramural fibroid have increased serum levels of follicle-stimulating hormone, luteinizing hormone, estradiol, and prolactin. Therefore, it was concluded that intramural fibroid affects higher serum concentrations of follicle-stimulating hormone, leitinizing hormone, estradiol, and prolactin as compared to PCOS. Due to this, it can contribute to the reduction of fertility or risk of miscarriage and complicated delivery in women with intramural fibroid.