ANTI-MULLERIAN HORMONE GENE POLY MORPHISM IN OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME

Abstract

Abstract: Polycystic ovary syndrome (PCOS), a complex condition that affects women of reproductive age, women with PCOS present higher prevalence of obesity. The purpose of the current research is to examine the possible relationship between polycystic ovary syndrome (PCOS) and Anti-mullarian hormone with their gene polymorphism (+430 T/G). The patients and controls women samples were collected during period May 2022 to March 2023. Its 140 participated in this study the ages of patients and control women ranged from 18 to 40 years old. These 140 person were divided into two groups: Group I: 70 obese control group and Group II: 70 obese PCOS group. Using amplification refractory mutation system (ARMS), also termed allele-specific PCR. In addition, serum specimens were collected for the measurement of many biochemical parameters. Showed that increased significantly in serum AMH and the frequencies of the G and T alleles were showed that there were significant differences between the case PCOS group and control. MDA parameter increased significantly while GPX1 decreased non significantly, about T-AOC the result of current study showed decreased significantly as compared to control group. Women with PCOS had a significantly higher mean in serum LH and Prolactin than control women, while FSH increased non significantly in PCOS patient when compared to control women. Women with PCOS had decreased significantly in GRA% and significant higher mean value in LYM%, PLYand WBC, respectively than control women, while RDW% decreased significantly in PCOS patient when compared to control women. The participants with homozygous for the G allele of the AMH (+430 T/G) showed an increased risk of PCOS and the value was statistically significant among obese women with polycystic ovary syndrome in Erbil city and associated with significant increase in serum Anti-mullarian hormone in PCOS group.