COLLAGEN III AND MATRIX METALLOPROTEINASE (MMP) 9 IN CERVICAL ELONGATION AND PELVIC ORGAN PROLAPSE: A NARRATIVE REVIEW
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Abstract
Cervical elongation is an extension or hypertrophy of the cervix towards the introitus with the supporting tissues of the uterus still in good condition. Knowledge regarding the pathogenesis of cervical elongation is still unclear. This review discusses cervical elongation and its association with the expression of collagen III and MMP 9. We searched for literature in the last five years through Google Scholar, PubMed, and Science Direct databases. Cervical elongation is a phenomenon that occurs when the cervix is longer than normal and is a co. Common but poorly defined problem in gynecology. Cervical prolongation is associated with efforts to manage patients with pelvic organ prolapse. Various studies reveal that there is a chance that collagen 3 and MMP-9 are associated with the incidence of cervical elongation. However, further research is still needed to find more specific and accurate results. Collagen is a fibrous protein that provides tensile strength to the skin, tendons, and bones. Changes in collagen content and structure can destroy the supporting function of the pelvic floor, which can lead to POP. Matrix metalloproteinase-9 (MMP-9) is a protease associated with the degradation of collagen and elastin. Increased activity of MMP-9 in vaginal tissue has been associated with pelvic organ prolapse.