COMPARISON OF THE EFFECT OF MORINGA EXTRACT AND THE DRUG ATORVASTATIN IN ALLEVIATING HISTOLOGICAL AND PHYSIOLOGICAL DISORDERS IN THE AORTA AND LIVER CAUSED BY HYPERLIPIDEMIA IN MALE RATS

Abstract

Abstract

This Research was designed to ascertain the impact of the hydroalcoholic extract of Moringa oleifera leaves in suppressing the tissue and physiological changes arising from male rat hyperlipidemia that was induced. The experiment was conducted for five weeks. The results showed a rise in the concentration of lipid profile, liver enzymes, and MDA, and a decrease in HDL-C and GSH in the affected group. As for the groups that were dosed with moringa leaf extract and the drug atorvastatin, they showed a decrease and normalization in the results. The results of the aortic tissue also showed many tissue abnormalities, separation of the elastic lamellae at a high rate, and infiltration. Inflammatory cells, degeneration of smooth muscle fibers, increased thickness of the aortic wall, and blood colloid increased in the negative control group. It also showed in the liver the presence of cirrhosis, thickening of the central vein wall, congestion of the blood vessel, infiltration of inflammatory cells, explosion and degeneration within the liver stroma, thickening of the nuclei, and the appearance of ghost cells. However, moringa leaf extract and the drug atorvastatin showed a positive role in improving and normalizing the tissue lesions in the aorta and liver resulting from excessive Fats. It is concluded that moringa leaf extract and atorvastatin together have a more effective role in improving and normalizing the tissue and physiological changes resulting from hyperlipidemia than using both moringa leaf extract and atorvastatin alone.