EVALUATING AND COMPARING THE OBSTETRIC OUTCOME IN ANTIPHOSPHOLIPID SYNDROME AND, SERO NEGATIVE ANTIPHOSPHOLIPID SYNDROME IN LOW SOCIO ECONOMIC GROUP.
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Abstract
Background: Antiphospholipid syndrome (APS) is an autoimmune disorder known to impact pregnancy outcomes, leading to complications such as recurrent miscarriage, thrombosis, and preeclampsia. Aim: This study aimed to comprehensively evaluate and compare obstetric outcomes in patients treated for APS, and seronegative APS (SN APS). Methods and Material: The study was conducted involving antenatal mothers with recurrent pregnancy loss or bad obstetric history. Patients were categorized into two groups: APS, and SN APS, based on specific diagnostic criteria. Each group received tailored treatment regimens according to their diagnosis. Patients were closely monitored throughout pregnancy, and obstetric outcomes were documented and analysed using statistical methods. Results: Among the observed complications, early pregnancy loss (EPL) was the most common adverse event. Preterm labour and preterm birth were frequent outcomes, Other complications included placental insufficiency and abruptio placenta. In terms of treatments, low-dose aspirin and LMW Heparin were commonly administered. The majority of preterm babies required neonatal intensive care unit (NICU) admission. Take home baby rate was 86%. Conclusion: This study highlights the significant obstetric challenges faced by patients with APS, and SN APS. The management of these conditions is complex, and timely treatment can lead to improved outcomes. Positive results in SN APS was in par with APS