METABOLIC SYNDROME AND ITS IMPACT ON CORONARY ARTERY DISEASE PROGRESSION: A LONGITUDINAL STUDY
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Abstract
A collection of metabolic irregularities known as metabolic syndrome (MetS) is linked to a higher risk of cardiovascular illnesses, such as coronary artery disease (CAD). Although there is ample evidence linking MetS to CAD, there aren't many long-term research examining how MetS affects the course of CAD. The results of a longitudinal study that looked at the connection between MetS and the evolution of CAD over time are presented in this paper. Even though many studies have identified a correlation between metabolic syndrome (MetS) and coronary artery disease (CAD), this relationship has not yet been summarized by a meta-analysis. Thus, the purpose of this study was to close this gap. Using electronic databases including PubMed, CINAHL Plus, Medline, and Web of Science, we carried out a methodical search. Ten investigations with 9,327 participants in all were included in the meta-analysis. When compared to people without MetS, MetS showed a strong correlation with an increased risk of CAD (OR = 4.03, 95% CI = 3.56–4.56). Furthermore, a significant correlation was found between each MetS component and a higher risk of CAD (OR = 3.72, 95% CI = 3.22–4.40). A high risk of coronary artery disease (CAD) was specifically linked to the presence of two (OR = 3.93, 95% CI = 2.81–5.49), three (OR = 4.09, 95% CI = 2.85–5.86), four (OR = 4.04, 95% CI = 2.83–5.78), or all five MetS components (OR = 3.92, 95% CI = 3.11–4.93). The most recent data emphasizes the connection between MetS, its constituent parts, and their combination with a higher risk of CAD. As a result, measuring MetS and its constituent parts may help identify people who are more likely to develop CAD later.