INTRAHEPATIC CHOLESTASIS OF PREGNANCY (IHCP): A CASE SERIES ANALYSIS

Abstract

Abstract

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder affecting pregnant women in the later trimesters. It is characterized by itching (pruritus) and elevated serum bile acids, potentially leading to adverse fetal outcomes. This study aimed to analyze the clinical presentation, diagnosis, and neonatal outcomes of ICP patients.

Methods: A retrospective review of seven pregnant women diagnosed with ICP at Saveetha Medical College was conducted. Data on symptoms, laboratory findings, management, and neonatal outcomes were collected and analyzed.

Results: All seven cases presented with pruritus, primarily on palms and soles. Liver function tests showed elevated levels of bilirubin, protein, liver enzymes (ALT, AST, ALP), and serum bile acid, while gamma-glutamyl transferase (GGT) remained normal. Delivery was performed in all cases, with some requiring cesarean sections due to fetal distress. Two newborns experienced mild respiratory distress at birth, requiring oxygen supplementation.

Conclusion: This case series highlights the typical presentation of ICP with pruritus and abnormal liver function tests, potentially leading to complications like fetal distress. Early diagnosis and management are crucial. Future research should explore the use of Ursodeoxycholic acid (UDCA) in these cases, investigate long-term neonatal outcomes, and utilize a larger patient group to identify risk factors and refine management strategies for ICP.