ASSESSMENT OF CARDIAC SPARING EFFECT IN INTRAUTERINE GROWTH RESTRICTED FETUSES: A PROSPECTIVE COHORT STUDY

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Hassan S Kamel, Amr M. Maghraby, Mohammed K. Ali
Tarek A. Abd Elsalam, Dina M. Habib, Sief Ali

Abstract

Abstract

Objective: The study aimed to find a difference in the cardiac output (COP) between normal and intrauterine growth restricted (IUGR) fetuses and to clarify a heart-sparing effect in IUGR fetuses (a new issue).


Material and methods: This single-center, prospective cohort study, was conducted at Assiut Woman's Health University Hospital, Egypt, prospectively registered at clinical trial.gov NCT03146507. Two hundred and ten women were included:  women with normal pregnancy (Group A:N=105) and women whose pregnancy was complicated by IUGR between 32 to 34 weeks gestation(Group B:N=105) from 2017 to 2022.  Women underwent fetal Doppler echocardiography, umbilical (UA), and middle cerebral (MCA) artery Doppler assessment. The primary outcome included the relative cardiac output ratio at 32-34 weeks. Changes in Doppler indices in the UA and MCA were also recorded. Data were analyzed by unpaired Student's t-test and Chi-square test.


Results: At 32-34 weeks and from 34 to 36 weeks; there was a higher value of right-side cardiac output in group A compared with group B; with a statistically significant difference (p=<0.001). While; the left-sided cardiac output was comparable in both groups; it was significantly higher in the IUGR group from 34 to 36 weeks.


Conclusion: There are significant changes in the cardiac output in IUGR fetuses in late pregnancy as compared with normal pregnancy thus confirming the hypothesis of heart sparing phenomenon.


 

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How to Cite
Mohammed K. Ali, H. S. K. A. M. M., & Sief Ali, T. A. A. E. D. M. H. (2024). ASSESSMENT OF CARDIAC SPARING EFFECT IN INTRAUTERINE GROWTH RESTRICTED FETUSES: A PROSPECTIVE COHORT STUDY. Obstetrics and Gynaecology Forum, 34(3s), 2411–2416. Retrieved from http://obstetricsandgynaecologyforum.com/index.php/ogf/article/view/719
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