ANTI-INFLAMMATORY CURING RUBIA CORDIFOLIA-MEDIATED ZINC OXIDE NANOPARTICLES

Abstract

Introduction: It is a medicinal plant commonly known as manjistha and has high therapeutic potential, used for conventional treatments of skin problems /disorders. The necessity for creating new vectors for the treatment of inflammation is sparked by the variety of inflammations brought on by external pathogens or chemicals, as well as mutations that upregulate inflammation enhancers. Nanoparticles have been employed in a variety of industries, including the food, cosmetics, and agricultural sectors, as well as in technological equipment including sensors, solar cells, and batteries.this study aims to find the anti inflammatory effect in rubia cordifolia mediated by zinc nanoparticles.

Objectives: The development of zinc oxide nanoparticles to investigate their anti-inflammatory activity.

Materials and Methods: Extraction of rubia cordifolia, preparation and filtration and addition of zinc nitrate solution with distilled water and stirring for three days (closed by using a foil) and the samples have been collected and observed

Results: With BSA assay, EA assay and membrane stabilization essay, it is concluded as

It has less inflammation factor (with inhibition and percentage )

Discussion: The zinc nanoparticles were modified which helped in achieving a better drug release in this present research indicating that the therapeutic effects of transdermal delivery are good. The nanosize of the particles enhanced their permeability and solubility, which increased the therapeutic effects. This was confirmed by the anti-inflammatory activity

Conclusion: Our results have shown that the RC extract contains various antioxidant compounds with anti-inflammatory effects.