DEVELOPMENT AND CHARACTERIZATION OF PLURONIC BASED THERMOSENSITIVE IN SITU GEL CONTAINING POSACONAZOLE FOR VAGINAL APPLICATION

Abstract

The aim of the present research was to formulate and evaluate thermoreversible in situ gel of Posaconazole for the treatment of vaginal candidiasis. Increased residence at the site of infection for a prolonged period of time makes the in situ gelling system more efficient with advantages of both gels and solution; like accuracy in dosing and ease of administration. The formulations of Posaconazole were prepared using Pluronic F-127 and Pluronic F-68 as thermo-sensitive agent and Carbopol 971P as mucoadhesive polymer. The formulations were evaluated for drug content, Gel strength, mucoadhesion, in-vitro diffusion and anti-fungal performance. The obtained results indicate that prepared formulations were found to release drug over the period of 8 Hrs. On basis of the results, it can be concluded that developed thermoreversible in situ vaginal gel of Posaconazole will be a better alternative to conventional dosage forms of Posaconazole improving patient compliance.