COMPARATIVE STUDY OF METFORMIN AND GLIBENCLAMIDE IN THE MANAGEMENT OF GESTATIONAL DIABETES MELLITUS AND PRE GESTATIONAL DIABETES MELLITUS

Abstract

This prospective observational comparative study aimed to compare the efficacy of metformin and glibenclamide, both individually and in combination with insulin, in managing gestational diabetes mellitus (GDM) and pre-gestational diabetes mellitus (pre-GDM). Our results showed that although glibenclamide had better glycemic control than metformin, it was associated with a greater incidence of adverse effects. Therefore, metformin should be considered as the safe first-line drug or drug of choice in patients with GDM and pre-GDM.